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The Official Parent's Sourcebook on Adrenoleukodystrophy Author: ICON Health Publications; Buy New: $28.95

The Official Parent's Sourcebook on Adrenoleukodystrophy Author: Icon Health Publications; Buy New: £22.95

Adrenoleukodystrophy (ald)

ALD is an inherited genetic disorder linked to the X sex chromosome. Because of the way genetic inheritance works, only boys have the most severe form of ALD. The disorder leaves the body unable to break down big fat molecules, Adrenoleukodystrophy ones the body makes itself or ones that enter the body through food. Recent research shows that this is most likely due to a carrier protein that fails to work correctly and carry the fat molecules to where they would be broken down. The fat molecules build up and clog up cells, and hurt nerve cells in the brain and spinal cord.

ALD is an X-linked recessive inheritance of a syndrome of Addison disease and cerebral sclerosis. It only affects males although neonatal autosomal ALD may also affect females. This neonatal form is clearly separate from the X-linked ALD. Symptoms often appear in boys between the ages of 4 and 8 and may include behavioral changes such as poor memory, loss of emotional control and dementia. Other symptoms may include muscle weakness, difficulties with hearing, speech and vision.

Adrenoleukodystrophy - A Medical Dictionary, Bibliography, a... Author: ICON Health Publications; Buy New: $34.95

Adrenoleukodystrophy - A Medical Dictionary, Bibliography, a... Author: ICON Health Publications; Buy New: £27.95

At this point there is no known cure for adrenoleukodystrophy, but there are various treatments available for the affected individual. One treatment is in the form of a bone marrow transplant.

Another somewhat controversial method of treatment is with a combination of vegetable oils named Lorenzo's oil after the son of the parents who developed it .

Adrenoleukodystrophy and other peroxisomal disorders

Adrenoleukodystrophy and Other Peroxisomal Disorders

Lorenzo’s Oil is a combination of two fats extracted from olive oil and rapeseed oil, respectively. This is an animated flash slide show that illustrates the mechanism of action of Lorenzo's Oil.

X-linked adrenoleukodystrophy Database  This database has been initiated to collect data on mutations found in the gene (ABCD1) responsible for X-linked adrenoleukodystrophy.

Adrenoleukodystrophy (ald)

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Adrenoleukodystrophy (ald)