Glucosamine Sulfate

From our list of ailments, see what Glucosamine Sulfate can be used for:

  • Arthritis
  • Carpal Tunnel Syndrome
  • Joint Pain
  • Pain

Natural Remedies using Glucosamine Sulfate

Additional sulfur, also essential for cartilage formation, can be obtained in glucosamine sulfate, chondroitin sulfate, or methylsulfonylmethane (MSM), and small amounts of manganese can be obtained in a multimineral supplement.

The two principal forms of glucosamine in supplements are glucosamine sulfate and glucosamine hydrochloride, and both appear to be equally effective. There is evidence suggesting that glucosamine and chondroitin sulfate are synergistic, with glucosamine enhancing the production of new cartilage and chondroitin slowing the breakdown of cartilage. Many supplements contain both, and people with osteoarthritis should consider taking 1,200 to 1,500 mg of glucosamine and 1,200 mg of chondroitin daily. As part of an osteoarthritic regimen, 500 to 1,000 mg of vitamin C should be included. Although some of the described studies used manganese ascorbate, this type of vitamin C is difficult to find. Any form of vitamin C should suffice.

Arthritis, Carpal Tunnel Syndrome, Joint Pain, Pain

The Benefit of using Glucosamine Sulfate as a natural cure

One way to maintain a lower biological age is to reduce tissue breakdown and the inflammation it stimulates. In a general way diets rich in vegetables and fruits provide large quantities of antioxidants, such as vitamin C, carotenoids, and flavonoids. These antioxidants neutralize damaging free radicals. For example, people who eat large amounts of antioxidant-rich vegetables develop fewer wrinkles and look younger. In a more specific example, many people take glucosamine sulfate supplements, which help maintain ‘younger” joints and reduce the pain of osteoarthritis.

A recent study by L. John Hoffer, M.D., Ph.D., of Jewish General Hospital, Montréal, suggested that the sulfur (sulfate), not the glucosamine, may be why glucosamine sulfate supplements help rebuild articular cartilage. Sulfur is essential for life, although it is not officially regarded as an essential nutrient. The mineral helps form many of the chemical bonds that hold together skin, collagen, cartilage, and other tissues.

In an article in the journal Metabolism, Hoffer pointed out that sulfur is needed for glycosaminoglycan synthesis. However, glucosamine sulfate supplements do not raise blood levels of glucosamine, while they do boost blood sulfur levels. The absorption of sulfur suggests that it is the more biologically active part of the compound, so Hoffer gave 1 gram of glucosamine sulfate to seven healthy subjects; three hours later they had a 13 percent increase in blood sulfur levels. These findings did not directly confirm that glucosamine sulfate helps in osteoarthritis, but they did suggest a biological explanation for why it might work. Also, Hoffer found that when the glucosamine sulfate was given along with acetaminophen (Tylenol), blood sulfur levels dropped by almost 11 percent.

Perhaps the most significant recent study was directed by Jean-Yves Reginster, M.D., of the University of Liège, Belgium. He and his fellow Belgian, Italian, and British researchers used digitized X rays to carefully measure the rate of knee cartilage damage in 106 patients with osteoarthritis. The patients then took either 1,500 mg of glucosamine sulfate or a placebo daily for three years.